Liver resident natural killer and T cells

A. PODHORZER; A. MACHICOTE; S. MONTAL; S. MARCIANO; O. GALDAME; P. BAZ, ; G. PODESTA; L. FAINBOIM.

Viena

Congreso; 4th European Congress of Immunology; 2015

Liver resident natural killer and T cellsAuthor Block: A. Podhorzer1, A. Machicote1, S. Montal2, S. Marciano3, O. Galdame3, P. Baz1, G. Podesta2, L. Fainboim1;1INIGEM, CABA, Argentina, 2Unidad de cirugía hepatobiliar y trasplante. Hospital Universitario Austral, CABA, Argentina, 3Hepatología, Hospital Italiano de Buenos Aires, CABA, Argentina. Abstract:Introduction: Most immunological studies on NK cells and T cells have focused on peripheral blood (PB) cells. The present study aimed to investigate liver microenvironment and determine differences between liver and peripheral blood (PB) NK and T cells. Material and Methods: NK receptors and T cells differentiation markers were analyzed on MNCs from PB healthy controls (N=32) or from liver perfusion collection from donor livers (N=10) The expression of surface markers was detected by flow cytometry Results: In comparison with PB, liver residentNK cells show increased frequencies of NKbright : 18% Vs 0.8; (p