INVESTIGADORES
FAINBOIM Leonardo
artículos
Título:
Depletion of circulating regulatory T cells during severe respiratory syncytial virus infection in young children
Autor/es:
RAIDEN, S; PANDOLFI, J.; PASYASLIAN, F.; ANDERSON, M.; RIVAROLA, N; FERRERO, F; URTASUN, M.; FAINBOIM, L.; GEFFNER, J; ARRUVITO, L.
Revista:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Editorial:
AMER THORACIC SOC
Referencias:
Lugar: New York; Año: 2014
ISSN:
1073-449X
Resumen:
Respiratory syncytial virus (RSV) is the main cause of viral lower
respiratory tractillnessininfancy and early childhood.Each year, RSVis
estimated to cause 34 million cases of lung infection and the deaths
of up to199,000 childrenless than5 years of ageworldwide.Children are
usually infected by RSV during the first year of life, and virtually all
by 3 years of age. Although in most cases the infection induces mild
illness of the upper airways, 2 to 5% experience a severe bronchiolitis
that requires hospitalization and respiratory support in an intensive
care unit. These patients show later a high susceptibility to develop
recurrent wheeze and asthma (1, 2).
Our current understanding of the host response to RSV
in humans remains rudimentary, because most observations
have been performed in animal models that do not adequately
reflect the course of human infection (3, 4). There is compelling
evidence, however, that the host immune response has
a prominent role in the pathogenesis of severe RSV infection
(3, 4). FOXP31CD41 regulatory T cells (Tregs) have emerged as
the most important cells able to prevent potentially harmful
immune responses (5). Observations made in animal models
clearly demonstrated that Tregs play a critical role in controlling
lung inflammation in the course of RSV infection (6?8). The
presence and function of Tregs during human RSV infection
have not been yet analyzed. We here show that severe RSV
infection of young children induces the selective depletion of
peripheral blood Tregs.