IAL   21557
INSTITUTO DE AGROBIOTECNOLOGIA DEL LITORAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila
Autor/es:
INGARAMO, MARÍA C.; ANDRES DEKANTY; SÁNCHEZ, JUAN A.
Lugar:
CABA
Reunión:
Congreso; 10th International Meeting of the Latin American Society of Developmental Biology; 2019
Institución organizadora:
LASDB
Resumen:
Coordinated intra- and inter-organ growth during animal development is essentialto ensure a correctly proportioned individual. The Drosophila wing has been a valuable model system through which to reveal a stress response mechanism mediated by Drosophila p53 (Dmp53) and involved in the coordination of tissuegrowth between adjacent cell populations upon targeted reduction of growth rates. Here we present evidence of a two-step molecular mechanism used by Dmp53 to reduce growth and proliferation in a non- autonomous manner. First, Dmp53-mediated transcriptional induction of Drosophila TNFα ligand Eiger leads to the cell-autonomous activation of JNK. Second, two distinct signaling events downstream of the Eiger/JNK axis are induced in the growth-depleted territory inorder to independently regulate tissue size and cell number in adjacent cellpopulations. Whereas expression of the hormone dILP8 acts systemically toreduce growth rates and tissue size of adjacent cell populations, the production of Reactive Oxygen Species - downstream of Eiger/JNK and as a consequence ofapoptosis induction - acts in a non-cell- autonomous manner to reduce proliferation rates. Our results unravel how local and systemic signals act concertedly within a tissue to coordinate growth and proliferation, thereby generating well-proportioned organs and functionally integrated adults.