miRNA Biogenesis: A Dynamic Pathway

MANAVELLA PA,; CAMBIAGNO DA,; ACHKAR NP,

TRENDS IN PLANT SCIENCE.

ELSEVIER SCIENCE LONDON

Lugar: Londres; Año: 2016 vol. 21 p. 1034 - 1044

1360-1385

MicroRNAs (miRNAs) modulate plant homeostasis through the inactivation of specific mRNAs, especially those encoding transcription factors. A delicate spatial/temporal balance between a miRNA and its targets is central to achieving the appropriate biological outcomes. In this review we discuss our growing understanding of the dynamic regulation of miRNA biogenesis. We put special emphasis on crosstalk between miRNA biogenesis and other cellular processes such as transcription and splicing. We also discuss how the pathway is regulated in specific tissues to achieve harmonious plant development through a subtle balance between gene expression and silencing.