Polyclonal dissemination of KPC-2 in Serratia marcescens, including a clone with epidemic behaviour in the nosocomial niche.

RODRÍGUEZ C, BRENGI S, CÁCERES MA, MOCHI S, VIÑAS MR, MERLETTI G, RAYA RR, CENTRÓN D.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2017

0924-8579

Serratia marcescens is a nosocomial pathogen frequently isolatedfromoutbreaks with high morbidity and mortality [1?3]. Several nosocomialoutbreaks have been described caused by the dispersion ofepidemic clones carrying class 1 integrons [1?3], some of which alsoharbour Klebsiella pneumoniae carbapenemase-2 (KPC-2) incarbapenem-resistant S. marcescens nosocomial isolates [3,4], renderingphenotypes of extreme antimicrobial resistance. Previously,we have identified multidrug-resistant (MDR) S. marcescens strainsbelonging to epidemic cluster IX circulating since 2002 in Argentiniannosocomial isolates [2]. This clusterwas susceptible to carbapenemsand harboured class 1 integrons. Later, a significant increase in thefrequency of carbapenem-resistant S. marcescens nosocomial isolates(19.5/11.9 absolute/expected annual frequency) was identifiedin a hospital of northern Argentina (H1) between 2013 and 2014.