INVESTIGADORES
CENTRON Daniela
artículos
Título:
Characterization of Tn6238 with a new variant of aac(6)-Ib-cr.
Autor/es:
QUIROGA MP, ORMAN, BE, ERRECALDE L, KAUFMAN S, CENTRÓN D.; DANIELA CENTRON.
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2015
ISSN:
0066-4804
Resumen:
Transposon Tn6238 is Tn1331-related recovered from a plasmid of an extensively drug-resistant Klebsiella pneumoniae clinical isolate with a new aac(6?)-Ib-cr variant. A de novo mutation in the origin of this bifunctional gene in a novel genetic platform is found according to bioinformatics analysis of both aac(6´)-Ib-like genes and attCaac(6?)-Ib-like sites. This is the first report of aac(6?)-Ib-cr in the Tn3 subfamily transposons, implying a novel way of dissemination of both aminoglycosides and fluoroquinolones resistance mechanisms.
