INVESTIGADORES
CENTRON Daniela
artículos
Título:
Class 1 Integrons Increase Trimethoprim-Sulfamethoxazole MICs against Epidemiologically Unrelated Stenotrophomonas maltophilia Isolates
Autor/es:
RAQUEL BARBOLLA, MARIANA CATALANO, BETINA E. ORMAN, ANGELA FAMIGLIETTI, CARLOS VAY, JORGELINA SMAYEVSKY,DANIELA CENTRÓN,1AND SILVIA A. PIÑEIRO
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
American Society for Microbiology
Referencias:
Lugar: Washington; Año: 2004 vol. 48 p. 666 - 669
ISSN:
0066-4804
Resumen:
Twenty-five plasmid-specified antimicrobial resistance determinants common to gram-negative bacilli from nosocomial infection were investigated from 31 Stenotrophomonas maltophilia isolates. Twenty-four clones were identified by pulsed-field gel electrophoresis, and in three clones that exhibited an increased trimethoprim-sulfamethoxazole MIC, the sul1 determinant was found. These results support not only the higher spread of class 1 integrons compared to other mechanisms but also the potential limitation of using trimethoprim-sulfamethoxazole for therapy of severe S. maltophilia infections.
