ESTROGEN RECEPTOR ALPHA IN CORONARY INTIMAL HYPERPLASIA IN CONGENITAL HEART DISEAS

CASTILLA ROCÍO; OTERO-LOSADA, MATILDE; MULLER, ANGÉLICA; KOLLIKER FRES, RODOLFO; AMBROSIO, GIUSEPPE; MILEI, JOSÉ

Atenas

Congreso; JOINT MEETING ESH-ISH - HYPERTENSION; 2014

International Society of Hipertension and European Society of Hipertension

PP.LB02.19 ESTROGEN RECEPTOR ALPHA IN CORONARY INTIMAL HYPERPLASIA IN CONGENITAL HEART DISEASE R. Castilla 1, M. Otero-Losada 1, A. Muller 1, R.A.  Kolliker Frers 1, G. Ambrosio 2, J. Milei 1.  1 Instituto de Investigaciones Cardiológicas, ININCA UBA CONICET, Buenos Aires, ARGENTINA, 2 Division of Cardiology, School of Medicine, University of Perugia, Perugia, ITALY   Objective: To study estrogen receptor alpha (ERalpha) expression in coronary intimal hyperplasia in children with congenital heart disease (CHD). These so considered preatherosclerotic lesions are highly frequent in pediatric patients with CHD. Activation of ERalpha might be a protective mechanism against vascular alterations by inhibition of smooth muscle cell proliferation and migration which are involved in intimal thickening formation. Design and method: Coronary  arteries from 57 hearts of CHD patients(mean 2.4 years old, 50.8% male, 52.6 % cyanotic type, 39% surgically repaired) and from 10 hearts of control children were used to analyze ERalpha expression by immunohistochemistry. Results: ERalpha expression was not related to sex or cyanotic characteristics. Expression in intimal  thickenings  was lower 8p < 0,01) and }the rate  of coronary intimal hyperplasia was higher (805 vs 475, P<0,02) in surgically treated patients than in non-surgically treated patients which showed values similar to controls. This difference was largely due to reduced intimalexpression of ERalpha whereas media layer expression was unchanged. Conclusions: Reduced ERalpha expression in intimal hyperplasia mightrepresent a risk factor for the development of coronary pre-atherosclerotic lesions development in CHD patients