INVESTIGADORES
CARPINELLA Maria Cecilia
artículos
Título:
Tyrosinase inhibitory activity of native plants from central Argentina. Isolation of an active principle from Lithraea molleoides
Autor/es:
CHIARI M.E.; JORAY M.B.; RUIZ G.; PALACIOS S. M.; CARPINELLA M.C.
Revista:
FOOD CHEMISTRY
Editorial:
Elsevier
Referencias:
Año: 2010 vol. 120 p. 10 - 14
ISSN:
0308-8146
Resumen:
Screening of 91 native plants from central Argentina was carried out with the aim of finding new sourcesof anti-tyrosinase compounds. Extracts obtained from Achyrocline satureioides, Artemisia verlotiorum,Cotoneaster glaucophylla, Dalea elegans, Flourensia campestris, Jodina rhombifolia, Kageneckia lanceolata,Lepechinia floribunda, Lepechinia meyenii, Lithrea molleoides, Porlieria microphylla, Pterocaulon alopecuroides,Ruprechtia apetala, Senna aphylla, Sida rhombifolia, Solanum argentinum, Tagetes minuta and Thalictrumdecipiens exhibited more than 90% inhibition of tyrosinase monophenolase activity at 1000 lgml1.D. elegans, L. meyenii and L. molleoides were the most potent with IC50 values of 0.48, 10.43 and 3.77lgml1, respectively. D. elegans, L. molleoides and T. decipiens also showed more than 90% inhibitionof diphenolase activity at 1000 lgml1, with the first of these being the most effective(IC50 = 49.27 lg ml1). (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol (1) was isolated from L. molleoides as aneffective tyrosinase inhibitor with L-tyrosine or L-DOPA as substrates (IC50 = 0.49 and 14.94 lgml1,respectively). Compound 1 was 37 times more active in monophenolase inhibitory activity than kojic acidused as a reference. Effective extracts as well as (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol could prove to bepromising preservative agents for use in the food industry.