INVESTIGADORES
CARPINELLA Maria Cecilia
artículos
Título:
Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina
Autor/es:
CARPINELLA M.C.*; ANDRIONE D.G.; RUIZ G.; PALACIOS S. M.
Revista:
PHYTOTHERAPY RESEARCH
Editorial:
John Wiley & Sons
Referencias:
Lugar: Hoboken, NJ, USA; Año: 2010 vol. 24 p. 259 - 263
ISSN:
0951-418X
Resumen:
Plants are a potential source of bioactive compounds and offer a promising strategy for the treatment of neurologicaldisorders such as Alzheimer?s disease.The inhibitory effect of 73 native and naturalized plants collected from the central region of Argentina onacetylcholinesterase (AChE) was tested using microplate and TLC assays after solvent fractionation of completeethanol extracts obtained from the plants.Organic fractions obtained from extracts of Achyrocline tomentosa (Asteraceae), Eupatorium viscidum(Asteraceae), Ruprechtia apetala (Polygonaceae) Trichocline reptans (Asteraceae) and Zanthoxylum coco(Rutaceae) presented strong inhibition of AChE (higher than 80%) at 1 mg/mL, with R. apetala and T.reptans being the most potent, showing complete inhibition of the enzyme. Their IC50 values were 0.0779 and0.1118 mg/mL, respectively. Aqueous fractions did not show any inhibitory activity on the enzyme. These resultssuggest that the most effective extracts deserve further investigation with the aim of obtaining new moleculesfor the treatment of neurodegenerative disorders.