INVESTIGADORES
CARPINELLA Maria Cecilia
artículos
Título:
Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides and its synergistic activity with commercial compounds
Autor/es:
CHIARI M.E.; JORAY M.B.; PALACIOS S. M.; CARPINELLA M.C.
Revista:
AAPS PHARMSCITECH
Editorial:
SPRINGER
Referencias:
Año: 2011 vol. 12 p. 795 - 796
ISSN:
1530-9932
Resumen:
(Z,Z)-5-(trideca-4,7-dienyl)-resorcinol showed a remarkable anti-tyrosinase activity being 8, 37 and 3 times more effective than L. molleoides extract, kojic acid or hydroquinone, respectively for monophenolase activity (L-tyrosine as substrate). In regard to diphenolase activity (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol was 5 and 9 times more effective than the extract of L. molleoides and hydroquinone respectively, but less active than kojic acid. (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol also showed a strong synergistic activity when combined with kojic acid. This combination exhibited about 90% inhibition when (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol and kojic acid were added at concentrations corresponding to 4 and 32 times below their IC90, respectively. No synergistic effect was observed with hydroquinone. According to these results (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol could arise as an effective anti-tyrosinase compound or being used in combinations with the commercial lightening agent kojic acid, with the aim of decreasing the effective doses of this last and in this way minimizing its side effects. References 1-Yi W, Wu X, Cao R, Song H and Ma L. Food Chem. 2009; 117:381?386. 2-Almeida-Paes R, Frases S, Fialho Monteiro PC, Gutierrez-Galhardo MC, Zancope-Oliveira RM et al. Microbes Infec. 2009; 11:554-562 3-Wu JJ, Lin JC, Wang CH, Jong TT, Yang HL, Hsu SL et al . J Supercrit Fluids. 2009; 50:33?41 4- Miyazaki I and Asanuma M. Neurochem Res. 2008; 34(4):698-706. 5-Qiu L, Chen QH, Zhuang JX, Zhong X, Zhou JJ, Guo YJ et al. Food Chem. 2009; 112: 609?613. 6- Zheng ZP, Cheng KW, Chao J, Wu J and Wang M. Food Chem. 2008; 106:529?535. 7-Chase MR, Raina K, Bruno J and Sugumaran M. Insect Biochem Molec. 2000; 30: 953?967. 8-Nosanchuk JD and Casadevall A. Cell Microbiol. 2003; 5(4): 203?223. 9-Nerya O, Musa R, Khatib S, Tamir S and Vaya J. Phytochemistry. 2004; 65:1389-1395. 10-Okombi S, Rival D, Bonnet S,Mariotte AM, Perrier E and Boumendjel A. Bioorg Med Chem Lett. 2006; 16: 2252?2255. 11-Karioti A, Protopappa A, Megoulas N and Skaltsa H. Bioorg Med Chem. 2007; 15:2708-2714. 12-Grupta AK., Gover MD, Nouri K. and Taylor S. J Am Acad Dermatol. 2006; 55:1048-1065. 13-Brenner M. and Hearing VJ. Drug Discov Today: Disease Mechanisms. 2008; 5(2):e189-e199. 14-Chawla S., deLong MA, Visscher MO, Wickett RR, Manga P and Boissy RE. Brit J Dermatol. 2008; 159:1267-1274. 15-Kim YJ and Uyama H. CMLS,Cell Mol Life Sci. 2005; 62:1707-1723. 16-Chiari ME, Joray MB, Ruiz G, Palacios SM and Carpinella MC. Food Chem. 2010; 120:10-14.