INVESTIGADORES
CAMPERI Silvia Andrea
congresos y reuniones científicas
Título:
ChemMatrix resin for the synthesis of complex peptides and combinatorial libraries
Autor/es:
J. TULLA-PUCHE; F. GARCÍA-MARTÍN; M. M. MARANI; M. PARADÍS-BAS; E. DE OLIVEIRA; Y. GARCÍA-RAMOS; S. A. CAMPERI; S. CÔTÉ; O. CASCONE; F. ALBERICIO
Lugar:
Canadá
Reunión:
Simposio; 20th American Peptide Society Symposium; 2007
Institución organizadora:
American Peptide Society
Resumen:
Enfurtivide (T-20 or fuzeon),  a 36-residue peptide which corresponds to 638 to 673 amino acid residues of the transmembrane protein gp41 from HIV-1, is the first fusion inhibitor for the treatment of HIV. Due to its highly hydrphobic sequence, large scale synthesis of T-20 has relied on a mixed solution-solid phase strategy, by synthesis shorter peptides on solid-phase , and coupling them in solution. We report here that by using ChemMatixm, a totally-based PEG resin which had performed excellently for the synthesis of complex and highly structured peptides, T-20 can be obtained in a stepwise manner, thus avoiding time-consuming steps such as precipitation and purification opf the peptide fragments. ChemMatix resin, which swells very well in biocomplatible solvents, can also be used for the synthsis 
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