INVESTIGADORES
CABRERA Gabriela Myriam
congresos y reuniones científicas
Título:
Antifungal compounds from X. prockia leaves
Autor/es:
MAIARA R. SALVADOR; MARIANY L. C. FOLLY; ANA A. SATHLER; GABRIELA F. FERREIRA; GABRIELA M. CABRERA; GASTON E. SILESS; KAREN L. LANG
Reunión:
Conferencia; 7th Brazilian Conference on Natural Products; 2019
Resumen:
Xylosma prockia, known as sucará, is a plant belonging to the family Salicaceae, native of Brazil, found mainly in the northeast, southeast and south of the country. There are no ethnobotanical reports on the medicinal use of the specie, as well chemical and pharmacological studies are scarce. Previous studies of this research group have found great potential for antifungal activity for X. prockia leaves, which justifies the present work. The aims of this study were the characterization of secondary metabolites in polar fractions of X. prockia leaves (SisGEN A66F830). The ethanolic extract was suspended in water for partition with solvents of increasing polarity, getting five fractions. Due to its best antifungal activity, the ethyl acetate fraction (EAF) was selected for chemical characterization. The HPLC-HRMS analysis of EAF obtained using ESI in the negative ionization mode allowed the visualization of fifteen major peaks, that were assembled in three distinct groups of compounds (I, caffeoyl-quinic acid derivatives; II, coumaroyl-glucosides derivatives; III caffeoyl-glucosides/deoxyhexosyl-caffeoyl glucosides derivatives).