Polyoxygenated steroids from the octocoral Leptogorgia punicea and in vitro evaluation of their cytotoxic activity

MARIA IZABEL GOULARTE MORITZ; LUCAS LOURENÇO MAROSTICA; ÉVERSON M. BIANCO; MARIA TEREZA R. ALMEIDA; JOÃO L. CARRARO; GABRIELA M. CABRERA; JORGE ALEJANDRO PALERMO; CLÁUDIA M. O. SIMÕES; ELOIR P. SCHENKEL

MARINE DRUGS

MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI

Lugar: Basel; Año: 2014 vol. 12 p. 5864 - 5880

1660-3397

Five new polyoxygenated marine steroids?punicinols A?E (1?5)?were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel.