Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity

SIMONE QUINTANA DE OLIVEIRA; MARIA TEREZA ROJO DE ALMEIDA; FLORA MARASLIS; IZABELLA THAÍS SILVA; THAIS CRISTINE MARQUES SINCERO; JORGE ALEJANDRO PALERMO; GABRIELA MYRIAM CABRERA; MIGUEL SORIANO BALPARDA CARO; CLÁUDIA MARIA OLIVEIRA SIMÕES; ELOIR PAULO SCHENKEL

PHYTOCHEMISTRY LETTERS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2012 vol. 5 p. 500 - 505

1874-3900

Investigation of the crude ethanolic extract obtained from the aerial parts of Dodonaea viscosa led to the isolation of three new ent-labdane diterpenes (1–3). The structures were established on the basis of their ESI–MS, UV, IR and NMR spectral data. The crude extract, fractions and compounds were evaluated for in vitro antiviral activity against Herpes Simplex Virus type 1 (HSV-1). The crude extract showed promising antiherpes activity expressed by a selectivity index of 6.2.