INVESTIGADORES
CABRERA Gabriela Myriam
artículos
Título:
Synthesis and preliminary biological screening of sterol analogues as new antifungal agents
Autor/es:
ALONSO, FERNANDO; ADRIANA M CIRIGLIANO; CABRERA GABRIELA M.; RAMIREZ JAVIER
Revista:
STEROIDS
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Año: 2010 vol. 75 p. 659 - 664
ISSN:
0039-128X
Resumen:
In this paper we report the synthesis of a new family of sterol analogues that have two amidic bonds on the side chain. These azasterols were obtained by a straightforward procedure including an Ugi condensation that allows the facile attachment of a polyfunctionalized side chain into the steroidal framework. Some of the new compounds showed an interesting inhibitory effect on the growth of two pathogenic fungi involved in plant diseases.