INVESTIGADORES
BOSCHETTI Carlos Eugenio
artículos
Título:
A Concise Synthesis of Piperazine-2-Carboxylic Acids via lactam Derived Amino Acid N-Carboxy Anhydrides
Autor/es:
CLAUDIO PALOMO,; IÑAKI GANBOA,; CARMEN CUEVAS,; CARLOS EUGENIO BOSCHETTI; ANTHONY LINDEN,
Revista:
TETRAHEDRON LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1997 vol. 38 p. 4643 - 4646
ISSN:
0040-4039
Resumen:
A route to piperazine-fused 3-hydroxy [3-1actams was accomplished via[2+2] cycloaddition of alkoxyketenes with imines derived from chiral a-aminoaldehydes and chiral 13-aminoalcohols. The resulting 13-1actams on exposure to 0.55MNaOC1 and a catalytic amount of 2,2,6,6-tetramethylpiperidinyl-l-oxyl (TEMPO)afforded co-amino acid N-carboxy anhydrides formally derived from piperazine-2-carboxylic acids.
