The thyroid status regulates triple negative breast cancer (TNBC) growth and metastasis through the modulation of mesenchymal stromal cell (MSC) migration and antitumor immune response

STERLE, HELENA; HILDEBRANDT, XIMENA; GUTIERREZ, LUCIANA M.; PAULAZO, ALEJANDRA; CAYROL, MARIA FLORENCIA; DIAZ FLAQUE, MARIA CELESTE; ROSEMBLIT, CINTHIA; BOLONTRADE, MARCELA F.; CREMASCHI, GRACIELA A.

Mar del Plata

Congreso; Reunión Conjunta de Sociedades de Biociencias, LXIII Reunión Anual SAIC, Sociedad Argentina de Investigación Clínica. SAI. SAFIS; 2018

SAIC, SAI, SAFIS

The association between thyroid disease and breast cancer risk remains unclear. Our aim was to evaluate the effect of thyroid status on TNBC development. For this, Balb/c mice were orthotopically inoculated with 4T1 cells after the treatment with thyroxine (12mg/l) for 30 days or propylthiouracil (500mg/l) for 15 days in the drinking water to obtain hyperthyroid (hyper) or hypothyroid (hypo) mice, respectively. An increased tumor growth rate, that became evident at day 21 post-inoculation (p.i.), was seen in hyper mice compared to controls (p