INVESTIGADORES
BOLONTRADE Marcela Fabiana
congresos y reuniones científicas
Título:
Mesenchymal stromal cells are modulated by a thyroid hormone-responsive tumor microenvironment
Autor/es:
AMORÓS, MARIANA A.; CAYROL, MARIA FLORENCIA; GUTIERREZ, LUCIANA M.; CERCHIETTI, LEANDRO; CORREA DOMINGUEZ, ALEJANDRO; LUZZANI, CARLOS; MIRIUKA, SANTIAGO; CREMASCHI, GRACIELA; BOLONTRADE, MARCELA F.
Lugar:
Mar del Plata
Reunión:
Simposio; LXI Reunión Anual SAIC SAI SAFE; 2016
Institución organizadora:
SAIC SAI SAFE
Resumen:
Mesenchymal Stromal Cells (MSC) are recruited and home in the tumor stroma. Functional properties such as immunomodulation, migration and secretion of paracrine factors turn MSC as modulators of the tumor environment. Identifying the niche components that modulate the cross talk between tumor cells and MSC is key to understand progression mechanisms. Tumor environmental factors may affect MSC functions, influencing their tumor modulation ability with an impact in tumor progression. In this regard thyroid hormones (TH) affect tumor growth. In order to study the contribution of MSC to tumor development we used our previously established model for T-cell lymphoblastic leukemia with MSCs as recruited tumor stromal cell components, evaluating the modulation exerted by TH on MSC in a tumor environment context. We demonstrated that TH-modulated tumor cells (canonical pathway) produced a secretome that induced lower migration rates and higher adhesiveness, together with an increased ability to induce angiogenesis in vitro and a higher proliferation rate on MSC. When tumor cells were modulated by TH via surface receptors (non-canonical pathway) the resultant secretome induced higher migration rates (252,6±35,49 vs 168,9±9,22 No. of cells/field, non-canonical vs canonical respectively, p