ILAV   21219
INSTITUTO DE INVESTIGACION EN LUZ, AMBIENTE Y VISION
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Integration of luminance, chromatic signals and melanopsin activation in human ipRGC processing
Autor/es:
BARRIONUEVO, PABLO A.; CAO, DINGCAI
Reunión:
Congreso; Society for Neuroscience 2015; 2015
Institución organizadora:
The Society for Neuroscience
Resumen:
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express melanopsin, a photopigment that can respond to light directly. In addition, these cells receive afferent inputs from rods and cones. Primate ipRGCs display S-OFF, L+M ON, and melanopsin ON response property. We investigated the integration of luminance and chromatic signals with melanopsin activation in ipRGCs processing by measuring human pupillary flickering responses. Using a lab-developed five primary photostimulator that can control the excitations of rods (R), three types of cones (S, M, L) and melanopsin-mediated ipRGCs (I) independently, we measured pupillary responses to sinusoidal stimuli that modulated rod, cone and melanopsin excitations in isolation or together but with relative phase varied. We used three types of cone stimuli, including cone luminance (LMS), equiluminant L vs. M [L/(L+M)], and S-cone (S) modulations. The temporal frequency was 1 Hz at 200 Td and 2000 Td. Consensual pupil recordings were obtained from the left eye with an EyelinkII eyetracker (Sampling rate 250Hz, spatial resolution