Photosensitized oxidation of BSA by novel ruthenium polypyridyl complexes with cyano substituents

MECCHIA ORTIZ, JUAN HUGO; MORÁN, EDUARDO; MIGNONE, RICARDO; KATZ, NÉSTOR E.; BORSARELLI, CLAUDIO

Córdoba

Encuentro; XI Encuentro Latinoamericano de Fotoquímica y Fotobiología; 2012

UNRC

Ruthenium (II) polypyridyl complexes (RPC) display excellent properties as both energy- or charge-transfer photosensitizers, which can be modulated with appropriate changes in ligand structure. The well recognized luminescence properties of their metal-to-ligand charge-transfer excited triplet states have led to their applications as suitable photoprobes for sensing and/or modification of biomolecules, such as DNA and proteins . Proteins are the most abundant macromolecules in biological environments. In particular, serum albumins are present in submimolar concentration in blood plasma, where their main function is the transport of fatty acids, among others. Recently, we have explored the photosensitized oxidation of both human (HSA) and bovine (BSA) serum albumins by using absorption and emission spectroscopies .In this work, we explored some aspects of the photosensitized oxidation of BSA by a series of novel mononuclear ruthenium complexes.