A Symmetrical Dirhenium(I) Complex with 4,4´´-azobis(2,2´-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer

SOTTILE, MARCO; KATZ, NÉSTOR E.; ABATE, PEDRO O.; VERGARA, MÓNICA M.; LEÓN, IGNACIO E.

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

SOC BRASILEIRA QUIMICA

Lugar: San Pablo; Año: 2020 vol. 31 p. 2299 - 2306

0103-5053

A new dinuclear complex of formula [{Re(CO)3(py)}2(μ-4,4´´-azobpy)](PF6)2, where py = pyridine and 4,4´´-azobpy = 4,4´´-azobis(2,2´-bipyridine), has been synthetized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by NMR measurements. When adding L-Cysteine or L-Glutathione, large and rapid changes in its UV-Vis absorption spectra were observed, which can be used for detecting both biologically relevant thiols. A promising activity for using this complex as a chemotherapeutic agent for bone cancer was also disclosed. Quantum mechanical calculations supported the experimental data.