INQUINOA   21218
INSTITUTO DE QUIMICA DEL NOROESTE
Unidad Ejecutora - UE
artículos
Título:
Volatiles from Subtropical Convolvulaceae That Interfere with Bacterial Cell-to-Cell Communication as Potential Antipathogenic Drugs
Autor/es:
MARIA VICTORIA PEREZ HENANDEZ; MARIO EDUARDO ARENA; MARÍA CONSTANZA LUCIARDI; ALICIA BARDÓN; NORA MURUAGA; ELENA CARTAGENA
Revista:
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Editorial:
OXFORD UNIV PRESS
Referencias:
Lugar: Oxford; Año: 2016 vol. 2016 p. 1 - 8
ISSN:
1741-427X
Resumen:
Increasing chronic bacterial infections create an urgent need for new antimicrobial agents or strategies for their control. Targetingvirulence is one of the alternative approaches to find new medicines to treat persistent infections due to bacteria with biofilmphenotypewhich are more resistant to antibiotics than their planktonic counterparts having an extreme capacity for evading the host defences. A bioguided study of sixteen extracts from flowers and leaves of four subtropical Convolvulaceae species provided evidence of the occurrence of antipathogenic natural products active against Gram positive and negative bacteria.Particularly, volatile metabolites from Merremia dissecta creeper, a food and medicinal plant, were able to interfere with the Pseudomonas aeruginosa quorum sensing system by a strong decrease of N-acyl homoserine lactone (AHL) biosynthesis (63?75%), which attenuated the virulence factor expression like biofilm (55%) and elastase activity (up to 27%), key factors thatenable the colonization and dissemination of the infection in the host. Control of the P. aeruginosa biofilm and the QS process by phytochemicals, such as (+) spathulenol, isolated from a bioactive extract of M. dissecta leaves would be a good strategy for the development of new and effective antipathogenic drugs.