INQUINOA 21218
INSTITUTO DE QUIMICA DEL NOROESTE
Unidad Ejecutora - UE
artículos
Título:
Sesqui-andtriterpenoidsfromtheliverwortLepidoziachorduliferainhibitorsofbacterialbiofilmandelastaseactivityofhumanpathogenicbacteria
Autor/es:
M.GILABERT; K.MARCINKEVICIUS; S.ANDUJAR; M.SCHIAVONE; M.E.ARENA; BARDON ALICIA DEL VALLE
Revista:
PHYTOMEDICINE
Editorial:
ELSEVIER GMBH
Referencias:
Año: 2015 vol. 22 p. 77 - 85
ISSN:
0944-7113
Resumen:
Fivedammarane-typetriterpenoids,fivepentacyclictriterpenoids(threeofthemcarryingacarboxylicacidgroup),andtwoaromadendrane-typesesquiterpenoidswereisolatedfromanArgentiniancollectionoftheliverwortLepidoziachordulifera.Compoundswerecharacterizedbycomparisonoftheirspectraldatawiththosepreviouslyreportedandtestedintheirabilitytocontrolbacterialgrowth,biofilmformation,bacterialQuorumSensingprocess(QS),andelastaseactivityofPseudomonasaeruginosa,aswellasbacterialgrowthandbiofilmformationofStaphylococcusaureus.Thekeyroleplayedbybiofilmandelastaseactivityinbacterialvirulencemakethemapotentialtargetforthedevelopmentofantibacterialagents.Thearomadendrane-typesesquiterpenoidviridiflorolwasthemostpotentbiofilmformationinhibitor,producing60%inhibitioninP.aeruginosaand40%inS.aureusat50μg/ml.Ursolicandbetulinicacids(twoofthepentacyclictriterpenoidsisolated)wereabletoreduce96and92%theelastaseactivityofP.aeruginosaat50μg/ml,respectively.Amongtheanalyzedtriterpenoids,thosethatcarryadammaraneskeletonwerethemostpotentinhibitorsoftheP.aeruginosabiofilmformationandwereactiveagainstbothP.aeruginosaandS.aureus.Subsequently,acomputer-assistedstudyofthetriterpenoidcompoundswascarriedoutforabetterunderstandingofthestructure-activityrelationships.
