Polyphenols rich fraction from Geoffroea decorticans fruits flour affects key enzymes involved in metabolic syndrome, oxidative stress and inflammatory process

COSTAMAGNA MILENA SOLEDAD; ZAMPINI IC; ALBERTO, ROSA; CUELLO, S; TORRES S; PEREZ J; QUISPE C; SCHMEDA-HIRSMANN; ISLA MI

FOOD CHEMISTRY

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2015 vol. 190 p. 392 - 402

0308-8146

Geoffroea decorticans (chañar), is widely distributed throughout Northwestern Argentina. Its fruit is consumedas flour, arrope or hydroalcoholic beverage. The chañar fruits flour was obtained and 39 phenoliccompounds were tentatively identified by HPLC-MS/MSn. The compounds comprised caffeic acid glycosides,simple phenolics (protocatechuic acid and vanillic acid), a glycoside of vanillic acid, p-coumaricacid and its phenethyl ester as well as free and glycosylated flavonoids. The polyphenols enriched extractwith and without gastroduodenal digestion inhibited enzymes associated with metabolic syndrome,including a-amylase, a-glucosidase, lipase and hydroxyl methyl glutaryl CoA reductase. The polyphenolicextract exhibited antioxidant activity by different mechanisms and inhibited the pro-inflammatoryenzymes (ciclooxygenase, lipoxygenase and phospholipase A2). The polyphenolic extract did not showedmutagenic effect by Ames test against Salmonella typhimurium TA98 and TA100 strains.These findings add evidence that chañar fruit flour may be considered a functional food with preventiveproperties against diseases associated with oxidative stress, inflammatory mediators and metabolicsyndrome.