INQUINOA 21218
INSTITUTO DE QUIMICA DEL NOROESTE
Unidad Ejecutora - UE
artículos
Título:
Tucupentol, a Novel Mono-tetrahydrofuranic acetogenin from Annona montana. A potent inhibitor of mitochondrial Complex I
Autor/es:
OLGA ALVAREZ COLOM; ADRIANA NESKE; NADIA CHAHBOUNE; M. CARMEN ZAFRA-POLO; ALICIA BARDÓN*
Revista:
Chemistry and Biodiversity
Editorial:
Verlag Helvetica Chimica Acta AG
Referencias:
Lugar: Zürich; Año: 2009 vol. 6 p. 335 - 340
ISSN:
1612-1872
Resumen:
Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1), is a mono-tetrahydrofuran-pentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cis-annonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range.
