BIOACTIVITY OF THE ESSENTIAL OIL OF AN ARGENTINE COLLECTION OF ACANTHOSPERMUM HISPIDUM (ASTERACEAE)

MARIANA ALVA; SUSANA POPICH; SUSANA BORKOSKY; ELENA CARTAGENA; ALICIA BARDÓN

NATURAL PRODUCT COMMUNICATIONS

NATURAL PRODUCTS INC

Lugar: Westerville, Ohio; Año: 2012 vol. 7 p. 245 - 248

1934-578X

The essential oil of an Argentine collection of the annual herb Acanthospermum hispidum DC. (Asteraceae), which contains the sesquiterpenoids beta-caryophyllene (35.2%), alpha-bisabolol (11.4%), and germacrene D (11.1%) as major constituents, displayed molluscicidal effects on an adult population of Biomphalaria peregrina Orbigny (LD50 37.8 μg/mL) and produced alteration of the feeding and oviposition behavior of the polyphagous insect Spodoptera frugiperda Smith when incorporated in the larval diet at 250 μg/g. In addition, a selective antibacterial activity was observed against pathogenic strains of Staphylococcus aureus and Enterococcus faecalis (MICs 62.5 and 125 μg/mL), but was inactive at 125 μg/mL against three beneficial lactic acid bacteria. Synergistic interactions were further validated by FIC index determination of the combination of the antibiotics oxacillin and gentamicin and the essential oil on the four pathogenic strains evaluated.