INVESTIGADORES
BIANCIOTTI Liliana Graciela
congresos y reuniones científicas
Título:
Promising therapeutic effect of coenzyme Q10 in ethynyl estradiol-induced cholestasis.
Autor/es:
MANUELA MARTINEFSKI; MYRIAN R. RODRIGUEZ; SILVIA LUCANGIOLI; LILIANA G. BIANCIOTTI; VALERIA TRIPODI
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC), LXIV Reu Anual de la Sociedad Argentina de Inmunología (SAI) y LXVIII Reunión Anual de la Sociedad de Farmacología Experimental (SAFE).; 2016
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
Intrahepatic cholestasis of pregnancy (ICP) is a high risk liverdisease given the eventual deleterious consequences that mayoccur in the fetous. ICP is characterized by the accumulation ofbile acids, particularly hydrophobic bile acids such as litocholic acid(LCA), which induces oxidative stress and apoptosis. We previouslyreported that women with IPC show decreased coenzymeQ10 (CoQ10) and enhanced bile acids in plasma. These findingswere also observed in ethinyl estradiol (EE)-induced cholestasisin rats. The aim of this work was to evaluate the effect of CoQ10supplementation in EE-induced cholestasis in rats. Cholestasiswas induced in Sprague-Dawley rats by a daily intraperitonealinjection of 5 mg/kg EE for 5 days (EE). A group of these rats also received daily oral 250 mg/kg CoQ10 supplementation for 5days (EE+CoQ10). Another group of rats received only CoQ10supplementation for the same period of time (CoQ10). Serum,bile acids (total and LCA), coenzyme Q9 (CoQ9) and CoQ10, aspartateaminotransferase, alanine aminotransferase, and alkalinephosphatase were assessed. Bile flow was also measured. Nodifferences were observed between CoQ10 and control groupsexcept for an increase in plasma CoQ10 (p