Effects of atrial natriuretic peptide and angiotensin III on the uptake and intracellular distribution of norepinephrine in medulla oblongata of the rat.

MARCELO S. VATTA; LILIANA G. BIANCIOTTI; MARIANA PAPOUCHADO; ANA SOL LOCATELLI; BELISARIO E. FERNANDEZ

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. C, COMPARATIVE PHARMACOLOGY AND TOXICOLOGY.

ELSEVIER SCIENCE BV

Lugar: Londres; Año: 1991 vol. 99 p. 293 - 297

0742-8413

Abstract-I. Ten micromoles angiotensin III decreased total 3H-norepinephrine uptake in medulla oblongata of the rat and 100nM atria1 natriuretic peptide increased it. These were the threshold concentrations for the peptides to modify the uptake of the amine. 2. A threshold concentrations (1 nM) of atria1 naturiuretic peptide reversed the effects produced by 10pM angiotensin III on total 3H-norepinephrine uptake, but subthreshold angiotensin III concentrations failed to alter the effects produced by 100 nM atria1 natriuretic peptide. 3. Angiotensin III, as well as atria1 naturiuretic peptide, modified only neuronal norepinephrine uptake and did not alter non-neuronal norepinephrine uptake. 4. Angiotensin III and atria1 naturiuretic peptide did not modify the intracellular distribution of norepinephrine in medulla oblongata