INVESTIGADORES
BELMONTE Silvia Alejandra
artículos
Título:
Mannose-6-phosphate receptors as a molecular indicator of maturation of epididymal sperm.
Autor/es:
BELMONTE, SILVIA A; ROMANO, PATRICIA; SOSA, MIGUEL ANGEL
Revista:
ARCHIVES OF ANDROLOGY
Editorial:
Ed. Taylor and Francis
Referencias:
Lugar: UK; Año: 2002 vol. 48 p. 51 - 61
ISSN:
0148-5016
Resumen:
This review discusses some of the changes in sperm during maturation within the context of current concepts of membrane structure and fertilization. Mammalian sperm are surrounded by a limiting plasma membrane that undergoes remodeling during passage through the epididymis. This process confers on the gamete vigorous motility and the ability to fertilize the egg. The repositioning of some surface proteins may follow redistribution of lipids in the plasmalemma, and thus represent a critical step in the maturation of the gametes. Among the various affected proteins of the sperm plasmalemma, mannose-6-phosphate receptors undergo redistribution as the gametes transit through the epididymal duct. The authors summarize their studies of the redistribution of phosphomannosyl receptors during maturation of sperm and discuss possible roles of these glycoproteins in the fertilizing capability of sperm.