MITOCHONDRIAL PEPTIDE HUMANIN (HN) ENHANCES CHEMORESISTANCE OF GLIOBLASTOMA CELLS

ASAD ANTONELA; ABT ARACELI A.; SEILICOVICH ADRIANA; ZUCCATO CAMILA; SAGRIPANTI SOFÍA; ROMANOWSKI VÍCTOR; NICOLA CANDIA ALEJANDRO JAVIER; PIDRE MATIAS LUIS; CANDOLFI MARIANELA

Mar del Plata

Congreso; LXIII Reunión Anual de la Sociedad Argentina de Investigación Cínica (SAIC); 2018

SAIC

Humanin (HN) is a mitochondrial-derivedpeptidewithpotentcytoprotective effect in many celltypes. Administration of HN hasbeen proposed as a therapeuticapproach for several chronicdiseases. Although HN has beenshown to protect normal tissuesagainst the toxic effects ofchemotherapy, its role in tumorchemoresistanceispoorlyunderstood. We aimed to evaluatewhether HN affects the sensitivityof GBM cells to chemotherapy.