Platelets and Extracellular Traps in Infections

GÓMEZ, RICARDO M; SCHATTNER, MIRTA; LÓPEZ ORTIZ, AÍDA O

PLATELETS

TAYLOR & FRANCIS LTD

Año: 2021 p. 1 - 9

0953-7104

Platelets have a well-recognized role in hemostasis and thrombosis, and they are importantamplifiers of inflammation and innate immune responses. The formation of DNA extracellulartraps (ETs) is a complex cellular mechanism, which occurs in response to microbial infectionsand sterile inflammation, and results in the release of DNA complexed with histones andvarious granular proteins. ETs were first discovered in neutrophils (NETs); however, it is nowaccepted that other leukocytes, including eosinophils (EETs) and monocytes/macrophages(MoETs/METs), can also generate them. Moreover, several types of ETs have been described.Increasing evidence has demonstrated that platelets modulate the formation of ETs. Thisreview summarizes recent findings about the physiopathological role of platelets in theformation of ETs during infection and future perspectives in the field.