Rare Detection of Bordetella pertussis Pertactin-Deficient Strains in Argentina

AISPURO, PABLO M.; BOTTERO, DANIELA; REGIDOR, VICTORIA; BARTEL, ERIKA; CARRIQUIRIBORDE, FRANCISCO; MAGALI, GABRIELLI; HOZBOR, DANIELA

EMERGING INFECTIOUS DISEASES

CENTERS DISEASE CONTROL

Año: 2019 vol. 25 p. 2048 - 2054

1080-6040

Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differgenotypically from strains used in production of pertussisvaccine. Pertactin-deficient strains are highly prevalentin countries that use acellular vaccine (aP), suggestingstrong aP-imposed selection of circulating bacteria. Tocorroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cellvaccine are needed. We provide pertussis epidemiologicdata and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000?2017.This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased atregular 4-year outbreaks; most cases were in infants