IBBM   21076
INSTITUTO DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Unidad Ejecutora - UE
artículos
Título:
First observation of neutrophil extracellular traps in human leptospirosis
Autor/es:
RICARDO GOMEZ; SCHARRIG E; RICARDO DRUT
Revista:
Case Reports in Clinical Pathology
Editorial:
Sciedu Press
Referencias:
Año: 2017
ISSN:
2331-2726
Resumen:
Leptospirosis is the most important global zoonosis and is caused by pathogenic spirochetes of the genus Leptospira. Human leptospirosis ranges in severity from a mild, self-limited febrile illness to a fulminant life-threatening one but their pathogenesis is still unclear. The extracellular release of the nuclear DNA of neutrophils, called NETs, upon activation by microbes is a pathogen-killing mechanism of neutrophils described in 2004 although its presence in human pathology have been observed only very recently. We report a case of fatal fulminant leptospirosis with associated severe pulmonary involvement and shown for the first time, evidence of the presence of NETs in the lung tissue.