IBBM   21076
INSTITUTO DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Unidad Ejecutora - UE
artículos
Título:
The Junín virus (JUNV) arenavirus is the etiologic agent of Argentina Haemorrhagic Fever (AHF). We characterised the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection
Autor/es:
NEGROTTO S; MENA HA; URE AE; JAQUENOD DE GIUSTI C; BOLLATI-FOGOLÍN M; VERMEULEN, EM; GÓMEZ RM
Revista:
JOURNAL OF VIROLOGY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2015 vol. 89 p. 7409 - 7413
ISSN:
0022-538X
Resumen:
The Junín virus (JUNV) arenavirus is the etiologic agent of Argentina Haemorrhagic Fever (AHF). We characterised the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection by the C#1 strain (attenuated), and even more, by the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expressions after infection with both JUNV strains.