IBBM 21076
INSTITUTO DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Unidad Ejecutora - UE
artículos
Título:
A blaVIM-2 plasmid disseminating in extensively drug-resistant clinical Pseudomonas aeruginosa and Serratia marcescens isolates
Autor/es:
VILACOBA, E.; QUIROGA, C.; PISTORIO, M.; FAMIGLIETTI, A.; RODRIGUEZ, H.; KOVENSKY, J.; DERASPE, M.; RAYMOND, F.; ROY, P.H. ; CENTRON, D.
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2014 vol. 58 p. 7017 - 7018
ISSN:
0066-4804
Resumen:
Infections caused by carbapenem-resistant 24 Enterobacteriaceae isolates are an issue of 25 major global concern (1). Genes coding for metallo-ß-lactamases (MßLs) identified in 26 clinical isolates are associated with mobile elements and subject to Horizontal Genetic 27 Transfer (HGT) events (2-6). VIM-2 is present on numerous plasmids, but only pNOR- 28 2000 from P. aeruginosa COL-1 from France (7-8), and pLD209 from P. putida LD209 29 from Argentina (9) have been completely sequenced. Here, we report the complete 30 sequence and characterization of plasmid pDCPR1 harboring a blaVIM-2 gene cassette in 31 a Tn402-type class 1 integron, which was isolated from two extensively drug-resistant 32 strains: P. aeruginosa 802 (burn patient at the Hospital Municipal de Quemados, 33 Argentina, 2005) and S. marcescens 68313 (Sanatorio Sagrado Corazón, Argentina, 34 2012).
