Plasma concentrations of incretins (GIP and GLP-1) did not increase in periparturient cows abomasally infused with glucose

M. LARSEN, A. E. RELLING, C. K. REYNOLDS AND N. B. KRISTENSEN

Clermont-Ferrand, France

Simposio; XIth international symposium on ruminant physiology,; 2009

ISRP International Scientific Committee

Increasing the glucogenic status of the periparturient cow by feeding diets containing bypass starch is, in theory, an attractive strategy to overcome the problems with hypoglycaemia and hyperlipidemia in early lactation. In a study with periparturient cows, Larsen and Kristensen (2009) found the dry matter intake (DMI) to be 37% lower when 1500 g/d of glucose were abomasally infused compared to non-infused cows. In humans, the incretin peptides, glucagon-like peptide 1(7-36) amide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) participate, directly and indirectly, in the hormonal regulation of appetite and glucose metabolism (Holst, 2004). Therefore, we hypothesised an increase in plasma concentrations of GLP-1 and GIP in periparturient cows abomasally infused with glucose.