IGEVET   21075
INSTITUTO DE GENETICA VETERINARIA "ING. FERNANDO NOEL DULOUT"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
CYTOMOLECULAR ANALYSIS OF RADIOMODULATOR POTENTIAL OF NATURAL COMPOUNDS
Autor/es:
ALBA M. GÜERCI
Lugar:
Montevideo
Reunión:
Congreso; X CONGRESO ALAMCTA; 2016
Institución organizadora:
ALAMCTA
Resumen:
While we have made substantial progress in recent decades in the prevention and control of oncological diseases, cancer remains one of the leading causes of death worldwide. It is assumed that diet and malnutrition, along with other factors that contribute to their development, are responsible for one-third of the malfunctions that occur. Thus, identification of natural dietary products that can be used preventively or therapeutically would be important for reducing disease risk and incidence and for the management of this condition as well. The idea that eating fruits containing bioactive substances has a protective potential on some disorders has been recently established. While the analysis of active ingredients of plants centered on the evaluation of antioxidants, the identification of polyphenols and associated substances allowed to discover their beneficial effects on health. In this regard, the chemopreventive and antitumor properties of some compounds are based on their antioxidant as well as anti-inflammatory and anti-proliferative activity. In tumor cells, a pro-oxidant behavior would be the basis for the dual action of any of these substances. Further, while low concentrations promote the protection of DNA damage induced by free radicals, high concentrations stimulate apoptosis and decreased mitotic index in cancer cells. This duality is particularly interesting in the field of radiotherapy. Therefore, the aim of our study was to find substances with radiomodulatory capacity to optimize the radiotherapeutic ratio. We evaluated by cytomolecular techniques in vitro genotoxic damage induced by joint treatment with blueberries and resveratrol and therapeutic X-ray doses, obtaining promising preliminary results, in line with the current literature. Agents that contribute to a decreased toxicity but maintaining tumor control should be investigated to avoid the side effects associated with these treatments.