IGEVET   21075
INSTITUTO DE GENETICA VETERINARIA "ING. FERNANDO NOEL DULOUT"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
OSSEOUS GROWTH MODIFICATIONS EVOKED BY HORMONAL TREATMENT IN PRENATAL GROWTH RETARDED RATS
Autor/es:
QUINTERO FA; LUNA ME; CASTRO L; CESANI MF; FUCINI MC; VILLANUEVA M; PRÍO V; GUIMAREY; OYHENART EE
Lugar:
La Plata, Argentina
Reunión:
Congreso; X Congreso de la Sociedad de Ciencias Morfológicas de La Plata y 7mas Jornadas de Educación; 2008
Institución organizadora:
Soceidad de Ciencias Morfológicas de La Plata
Resumen:
It has been postulated that intrauterine growth retardation (IUGR) it causes postnatal sex-dependent consequences. Experimental model of partial binding of the uterine arteries leads to modifications of fetal growth by placental insufficiency. The aim of this study was to analyze the postnatal growth off rats with IUGR treated with Growth hormone (Gh) and sexual hormones. Rats Wistar was divided into the following groups: Control, IUGR (induced by partial obstruction of the uterine arteries on day 14 of gestation) and Sham Operated. The IUGR group was divided into the following subgroups: IUGR; IUGR plus GH (GH), IUGR castrated (Ca), IUGR castrated plus GH (Ca+GH), IUGR treated with testosterone (Te) and estradiol (Es). IUGR was. The animals were x-rayed at 1, 21, 42, 63, and 84 days of age and the following dimensions of bones were measured: the length, width, and height of the neuro- and splanchnocranium; the length of the vertebral column; the pelvic length and the upper, middle, and lower pelvic widths; and the lengths and the widths of the humerus, femur, and tibia. The data were analyzed by analysis of variance (ANOVA); multiple-range, minimal-significant-difference (LSD) and multiple-correlation tests. We concluded that IUGR modify every metrics variables in both sexes. The castration increases growth in females and inhibits growth in males. Testosterone produced a mosaic-effect growth in long bones while Estradiol inhibits global growth. GH activity causes sex-dependent response.