EXPRESSION OF GIP RECEPTOR IN THE BOVINE CUMULUS OOCYTE COMPLEX.

PASCUA AM; SIRINI MA; ANCHORDOQUY JM; ANCHORDOQUY JP; FURNUS CC; RELLING AE

Jornada; XVI Jornadas Anuales de la Sociedad Argentina de Biología; 2014

The glucose-dependent insulinotropic polypeptide (GIP) is an hormone released by the duodenum. In ruminants, GIP concentration increases when the energy balance changes from negative to positive .In cattle, GIP decreases the rate of lipolysis in subcutaneous adipose tissue and plays an important role in the regulation of the energy use (energy partition). So far, there are not studies linking GIP with reproductive function. Until now, it has not been demonstrated the presence of GIP receptor in bovine reproductive tissues. The aim of this study was to investigate the mRNA expression of GIP receptor in bovine cumulus oocyte complex (COC). Oocyte-cumulus complex were aspirated from bovine ovaries. The presence of GIP receptor in the bovine COC was evaluated by PCR. We demonstrated that GIP receptor was expressed in the immature COCs bovine.These data strongly suggest that GIP may have a potential regulatory action in the control of oocyte maturation.