Evaluation of Angiogenesis with the Expression of VEGF-C and CD34 in Human Colon Cancer

INDA AM,GARCÍA MN, ANDRINI LB, GARCIA AL, FERNÁNDEZ BLANCO A, FURNUS C, GALLETTI SM, BRANDONI J, MARTÍNEZ JG, PRAT GD, ERRECALDE AL.

Current Chemical Biology

Bentham Science Publishers Ltd.

Lugar: Oak Park, IL, USA; Año: 2009 p. 302 - 305

1872-3136

Abstract: Background: The most potent angiognic factor is the vascular endothelial growth factor (VEGF), and CD34 is an endothelial antigen that has been used to highlight the microvasculature vessel density (MVD) as a direct marker of the degree of neoangiogenesis. In the present study we report that VEGF expression and its relationship with MVD, in poorly and well differentiated colon adenocarcinoma, in order to consider the possibility of using the correlation between both antibodies as a prognostic factor. Materials and Methods: Tumor sections were stained by immunohistochemistry for CD34 and VEGF. Results: The mean of VEGF and CD34 did not show any significant differences between both types of tumors. Conclusion: The conventional factors taken into consideration were not significantly related to the angiogenic factors examined, so we could affirm that the correlation of both markers could be useful as prognostic factor.