IGEVET   21075
INSTITUTO DE GENETICA VETERINARIA "ING. FERNANDO NOEL DULOUT"
Unidad Ejecutora - UE
artículos
Título:
Assessment of biodiversity in Chilean cattle using the distribution of major histocompatibility complex class II BoLA-DRB3 allele.
Autor/es:
TAKESHIMA, SN; MIYASAKA, T; MATSUMOTO, Y; XUE, G; DIAZ, V; ROGBERG MUÑOZ, A; GIOVAMBATTISTA, G; ORTIZ, M; OLTRA, J; KANEMAKI, M; ONUMA, M; AIDA, Y
Revista:
TISSUE ANTIGENS
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2015 vol. 83 p. 35 - 44
ISSN:
0001-2815
Resumen:
Bovine leukocyte antigens (BoLAs) are used extensively as markers for
bovine disease and immunological traits. In this study, we estimated
BoLA-DRB3 allele frequencies using 888 cattle from 10 groups, including
seven cattle breeds and three crossbreeds: 99 Red Angus, 100 Black
Angus, 81 Chilean Wagyu, 49 Hereford, 95 Hereford × Angus, 71 Hereford ×
Jersey, 20 Hereford × Overo Colorado, 113 Holstein, 136 Overo Colorado,
and 124 Overo Negro cattle. Forty-six BoLA-DRB3 alleles were
identified, and each group had between 12 and 29 different BoLA-DRB3
alleles. Overo Negro had the highest number of alleles (29); this breed
is considered in Chile to be an 'Old type' European Holstein Friesian
descendant. By contrast, we detected 21 alleles in Holstein cattle,
which are considered to be a 'Present type' Holstein Friesian cattle.
Chilean cattle groups and four Japanese breeds were compared by
neighbor-joining trees and a principal component analysis (PCA). The
phylogenetic tree showed that Red Angus and Black Angus cattle were in
the same clade, crossbreeds were closely related to their parent breeds,
and Holstein cattle from Chile were closely related to Holstein cattle
in Japan. Overall, the tree provided a thorough description of breed
history. It also showed that the Overo Negro breed was closely related
to the Holstein breed, consistent with historical data indicating that
Overo Negro is an 'Old type' Holstein Friesian cattle. This allelic
information will be important for investigating the relationship between
major histocompatibility complex (MHC) and disease.