Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle

LIRON, J.P.; PRANDO A.J.; FERNANDEZ M.E.; RIPOLI M.V.; ROGBERG MUÑOZ A.; GOSZCZYNSKI D.E.; POSIK D.M.; PERAL GARCIA P.; BALDO A.; GIOVAMBATTISTA, G.

BMC GENETICS

BIOMED CENTRAL LTD

Lugar: Londres; Año: 2012 vol. 13 p. 26 - 26

1471-2156

Background In bovines, there are significant differences within and among beef breeds in the time when bulls reach puberty. Although the timing of puberty is likely to be a multigenic trait, previous studies indicate that there may also be single genes that exert major effects on the timing of puberty within the general population. Despite its economic importance, there are not many SNPs or genetic markers associated with the age of puberty in male cattle. In the present work, we selected three candidate genes, GNRHR, LHR and IGF1, and associated their polymorphisms with the age of puberty in Angus male cattle. Results After weaning, 276 Angus males were measured every month for weight (W), scrotal circumference (SC), sperm concentration (C) and percentage of motility (M). A total of 4 SNPs, two within GNRHR, one in LHR and one in IGF1 were genotyped using the pyrosequencing technique. IGF1-SnaBI SNP was significant associated (P