IGEVET 21075
INSTITUTO DE GENETICA VETERINARIA "ING. FERNANDO NOEL DULOUT"
Unidad Ejecutora - UE
artículos
Título:
XRCC1 ARG399GLN POLYMORPHISM AND RISK FOR CERVICAL CANCER DEVELOPMENT IN ARGENTINE WOMEN.
Autor/es:
BARBISAN G; PEREZ LO; DI FRANZA L; FERNANDEZ C; CIANCIO N; GOLIJOW CD
Revista:
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
Editorial:
I R O G CANADA, INC
Referencias:
Lugar: Vancouver; Año: 2011 vol. 32 p. 274 - 279
ISSN:
0392-2936
Resumen:
Background: XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the base excesion repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. Materia and Methods: we conducted a case control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. Results: Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associatted with a decreased risk for cervical carcinoma. Conclusions: Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.
