IGEVET   21075
INSTITUTO DE GENETICA VETERINARIA "ING. FERNANDO NOEL DULOUT"
Unidad Ejecutora - UE
artículos
Título:
Association of canine juvenile generalized demodicosis with the dog leukocyte antigen system
Autor/es:
IT V.; BARRIENTOS L.; LOPEZ GAPPA J.; POSIK D.M.; DIAZ S.; GOLIJOW C.D.; GIOVAMBATTISTA G.
Revista:
TISSUE ANTIGENS
Editorial:
Willey Interscience
Referencias:
Año: 2010 vol. 76 p. 67 - 70
ISSN:
0001-2815
Resumen:
Demodectic mange is a well-known parasitic skin disease characterized by the presence of a larger than normal number of Demodex mites (Demodex canis) in the skin of dogs.  Recent research has suggested that MHC class II expression is higher in the skin of dogs suffering from demodicosis than in normal ones. We have investigated whether Canine Dog Leukocyte Antigen (DLA) class II alleles are associated with canine juvenile generalized demodicosis. In the present study, the analysis of microsatellite markers (FH2202, FH2975 and FH2054) linked to DLA was made in boxer, Argentinean mastiff and mixed breed dogs. DNA samples from 56 dogs affected with the disease and 60 breedmatched controls collected in Argentina were analyzed. A highly significant association, in some of the analyzed markers, in all breeds with the presence of demodicosis was observed with p < 0.05 and OR ¡Ý 5. The results of this study suggest that an underlying  DLA association exists with demodicosis in dogs and that this may represent an important immunological risk factor in the aetiology of this condition. This information could be used in the future to develop diagnostic tests to prevent canine juvenile generalized demodicosis. Demodex canis) in the skin of dogs.  Recent research has suggested that MHC class II expression is higher in the skin of dogs suffering from demodicosis than in normal ones. We have investigated whether Canine Dog Leukocyte Antigen (DLA) class II alleles are associated with canine juvenile generalized demodicosis. In the present study, the analysis of microsatellite markers (FH2202, FH2975 and FH2054) linked to DLA was made in boxer, Argentinean mastiff and mixed breed dogs. DNA samples from 56 dogs affected with the disease and 60 breedmatched controls collected in Argentina were analyzed. A highly significant association, in some of the analyzed markers, in all breeds with the presence of demodicosis was observed with p < 0.05 and OR ¡Ý 5. The results of this study suggest that an underlying  DLA association exists with demodicosis in dogs and that this may represent an important immunological risk factor in the aetiology of this condition. This information could be used in the future to develop diagnostic tests to prevent canine juvenile generalized demodicosis. ¡Ý 5. The results of this study suggest that an underlying  DLA association exists with demodicosis in dogs and that this may represent an important immunological risk factor in the aetiology of this condition. This information could be used in the future to develop diagnostic tests to prevent canine juvenile generalized demodicosis. Demodex canis) in the skin of dogs.  Recent research has suggested that MHC class II expression is higher in the skin of dogs suffering from demodicosis than in normal ones. We have investigated whether Canine Dog Leukocyte Antigen (DLA) class II alleles are associated with canine juvenile generalized demodicosis. In the present study, the analysis of microsatellite markers (FH2202, FH2975 and FH2054) linked to DLA was made in boxer, Argentinean mastiff and mixed breed dogs. DNA samples from 56 dogs affected with the disease and 60 breedmatched controls collected in Argentina were analyzed. A highly significant association, in some of the analyzed markers, in all breeds with the presence of demodicosis was observed with p < 0.05 and OR ¡Ý 5. The results of this study suggest that an underlying  DLA association exists with demodicosis in dogs and that this may represent an important immunological risk factor in the aetiology of this condition. This information could be used in the future to develop diagnostic tests to prevent canine juvenile generalized demodicosis. ¡Ý 5. The results of this study suggest that an underlying  DLA association exists with demodicosis in dogs and that this may represent an important immunological risk factor in the aetiology of this condition. This information could be used in the future to develop diagnostic tests to prevent canine juvenile generalized demodicosis.