INVESTIGADORES
ALVAREZ Luis Ignacio
artículos
Título:
Feeding Management and Albendazole Pharmacokinetics in Pigs
Autor/es:
IGNACIO, ALVAREZ LUIS; VALENTINA, CHIAPPETTA; LUCILA, MORIONES; PAULA, DOMINGUEZ; CANDELA, CANTÓN; CARLOS, LANUSSE; LAURA, CEBALLOS
Revista:
Animals
Editorial:
Multidisciplinary Digital Publishing Institute
Referencias:
Lugar: Basel; Año: 2023 vol. 13
ISSN:
2076-2615
Resumen:
Albendazole (ABZ) is a methylcarbamate benzimidazole anthelmintic used to controlgastrointestinal parasites in several animal species and humans. The type of diet has been identifiedas a major determinant for ABZ pharmacokinetics in different animal species and humans. The workdescribed here assesses the pattern of the absorption and the systemic availability of ABZ and itsmetabolites after its oral administration to pigs under different feed management plans. Eighteen pigs(5 months old, local ecotype breeds) were distributed into three experimental groups. In the fastinggroup, the animals fasted for 8 h prior to treatment. In the pellet + oil and pellet groups, the animalswere fed ad libitum with a commercial pelleted-based diet with or without the addition of soya oil.An ABZ suspension was orally administered at 10 mg/kg. Blood samples were taken over the 48 hpost-treatment. The plasma samples were analyzed by HPLC. Under the described experimentalconditions, the ingestion of the pellet-based diet with or without the soya oil before ABZ treatmentdid not significantly (p < 0.05) modify the plasma disposition kinetics of the ABZ sulfoxide (ABZSO,the main ABZ metabolite) compared to that observed in the fasting pigs. Both ABZ metabolites(ABZSO and ABZ sulphone) reached similar peak concentrations and systemic exposures in all theexperimental groups regardless of the feeding management. However, the addition of oil to thepelleted food enhanced the pattern of ABZ absorption, which was reflected in the higher (p < 0.05)concentration profiles of the active ABZSO metabolite measured between 12 and 48 h post-treatmentcompared to the pigs fed with the pelleted food alone. Although this effect may not be therapeuticallyrelevant after ABZ administration as a single oral dose, the overall impact of the type and feedingconditions when ABZ is supplemented with food for several days should be cautiously evaluated