Regulación de la respuesta celular a la hipoxia.

PODEROSO JJ

Mar del Plata, Buenos Aires

Conferencia; LIV Reunión Anual de la SAIC.; 2009

Sociedad Argentina de Investigación Clínica

Mitochondria consume more than 90% of available oxygen. The physiological pO2 in the mitochondrial environment is considerably lower than in blood circulation, and circa 5-10 Torr depending on the different tissues. However, at that low O2 level, mitochondria still work properly due to the high rate of electron transfer to O2 by cytochrome oxidase (COX). COX has a very low Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. work properly due to the high rate of electron transfer to O2 by cytochrome oxidase (COX). COX has a very low Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. work properly due to the high rate of electron transfer to O2 by cytochrome oxidase (COX). COX has a very low Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. environment is considerably lower than in blood circulation, and circa 5-10 Torr depending on the different tissues. However, at that low O2 level, mitochondria still work properly due to the high rate of electron transfer to O2 by cytochrome oxidase (COX). COX has a very low Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. work properly due to the high rate of electron transfer to O2 by cytochrome oxidase (COX). COX has a very low Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. work properly due to the high rate of electron transfer to O2 by cytochrome oxidase (COX). COX has a very low Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. environment is considerably lower than in blood circulation, and circa 5-10 Torr depending on the different tissues. However, at that low O2 level, mitochondria still work properly due to the high rate of electron transfer to O2 by cytochrome oxidase (COX). COX has a very low Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. work properly due to the high rate of electron transfer to O2 by cytochrome oxidase (COX). COX has a very low Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. work properly due to the high rate of electron transfer to O2 by cytochrome oxidase (COX). COX has a very low Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS. Km for oxygen in the 10-7-10-8 M range, and it is  regulated by increase of mtNOS.