Kinases and mitochondrial cycling: the last encounter

CARRERAS MC, PODEROSO JJ

Mitochondrial signaling in Health and Disease.

CRC Press

Año: 2012; p. 191 - 296

Mitochondria are connected to cell kinase pathways, and evolution of kinases represents modular changes that amplify the extent and topology of target molecules. In this context, kinases reached mitochondria and obtained access to phosphorylation and a functional redox control. Both effects bring up conformational changes mostly based on cysteine oxidation with two important biological consequences: First, different kinases are activated at high or low redox status, and proliferation or cell death is decided. Second, kinases are “informed” about the mitochondrial status, and therefore, cell cycle follows the energy level of the endosymbiotic organelles.