Fluoxetine revert memory impairment in a depressive animal model.

PORETTI MB; PONZIO MF; FIOL DE CUNEO M; CARLINI VP

Huerta Grande, Cordoba

Congreso; II Reunion Conjunta de Neurociencias (IRCN) y Sociedad Argentina de Neurociencia (SAN),; 2010

Sociedad Argentina de Neurociencia

Psychiatric disorders, including depression, are complex and heterogeneous clinical entities. The depressive state is characterized by a core conjunct of psychopathological phenomena, among which is included the short and long-term memory impairment (Chestnut et al, 2008). The launch to fluoxetine market, a selective reuptake inhibitor, was the beginning of a new era of safe and effective treatment for patients with depression; however its impact in memory processes has nevertheless not been explained. In the present study we investigated the F effect on memory in a depression animal model (olfatory bulbectomy). Male albino¡¯s Swiss mice were divided in two groups: sham (C) and bulbectomiced (BO). After 15 days of surgery it were evaluated in tail suspension test in order to determine a depressive behavior and them it were treated orally with saline (S) or F (10 mg/Kg) during 28 days. The last day, memory retention was evaluated using the objects recognition test. C-F and BO-S animals showed memory impairment in relation to C-S animals (F(68,2)= 39.50, p¡Ü 0.05), and BO-F animals showed memory enhancement in relation to BO-S (F(134,4)= 3.18, p¡Ü 0.05). In conclusion, F revert memory impairment in BO animals and exhibited a different effect depending the physiological condition.