Subclinical lower airways correlates of chronic allergic and non-allergic rhinitis

SARANZ, RICARDO J.; LOZANO, ALEJANDRO; LOZANO, NATALIA A.; PONZIO, MARINA F.; CRUZ, ÁLVARO A.

CLINICAL AND EXPERIMENTAL ALLERGY

WILEY-BLACKWELL PUBLISHING, INC

Año: 2017

0954-7894

The upper and lower airways behave as a physiological and pathophysiological unit. Subclinical lower airways abnormalities have been described in patients with rhinitis without asthma. These are expressed as bronchial hyperreactivity, abnormalities in lung function and bronchial inflammation, likely as a result of the same phenomenon with systemic inflammatory impact that reaches both the nose and the lungs, which for unknown reasons does not always have a full clinical expression. Patients with rhinitis are at increased risk of developing asthma; therefore most authors suggest a careful clinical evaluation and monitoring of these patients, especially if symptoms related to inflammation in the lower airways are observed. Although current treatments, such as H1-antihistamines, intranasal steroids and allergen immunotherapy are quite effective for the management of rhinitis, it is difficult to prove their capacity to prevent asthma among subjects with rhinitis. Evidence showing that the treatment of rhinitis has a favorable impact on indicators of bronchial hyperreactivity and inflammation among subjects that have no symptoms of asthma, is more frequently described. In this review we address the frequency and characteristics of lower airway abnormalities in subjects with rhinitis, both in pediatric and adult populations, their likely predictive value for the development of asthma and the possibilities for therapeutic intervention that could modify the risk of subjects with rhinitis towards presenting asthma.